Phosphomannose Isomerase (PMI)
Phosphomannose Isomerase (PMI)
Phosphomannose isomerase (PMI/MPI), phosphomannose mutase (PMM), and GDP-Man pyrophosphorylase (GMPP) are the three crucial enzymes involved in the biosynthesis of GDP-Man, which is required for cell wall mannan biosynthesis and protein glycosylation. UDP-glucose (UDP-Glc), UDP-GlcNAc, and GDP-Man are the three precursors required for cell wall biosynthesis. PMI catalyzes the conversion between fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P)[1]. This enzyme is present in mammals, bacteria, and fungi and plays an important role in cell wall synthesis, viability, and cell signaling. PMI deficiency is associated with congenital disorder of glycosylation. PMI inhibition combined with mannose supplementation might help normalize N-glycosylation and improve CDG-Ia pathology[2].
References:
- [1]. Usman S, et al. Loss of Phosphomannose Isomerase Impairs Growth, Perturbs Cell Wall Integrity, and Reduces Virulence of Fusarium oxysporum f. sp. cubense on Banana Plants. J Fungi (Basel). 2023 Apr 16;9(4):478. [Content Brief]
- [2]. Sharma V, et al. Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts. J Biol Chem. 2011 Nov 11;286(45):39431-8. [Content Brief]
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Phosphomannose Isomerase (PMI) Related Products (4)
Related Products (4)
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MLS0315771
0 ImagesMLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC50 ~1 μM and a Ki of 1.4 μM.
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ML089
0 ImagesML089 is an orally active inhibitor of phosphomannose isomerase (PMI) and PHOSPHO1, with an IC50 value of 1.3 μM against human PMI and an IC50 value of 0.8 μM against PHOSPHO1. ML089 blocks the catabolism of mannose-6-phosphate, directs mannose-6-phosphate to participate in protein glycosylation, increases mannose incorporation into cellular proteins, and reduces tritiated water production from mannose-6-phosphate. ML089 inhibits PMI in living cells. ML089 can be used in research related to congenital disorder of glycosylation type Ia (CDG-Ia).
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Thr101
0 ImagesThr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia).
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α-D-Glucose 1,6-bisphosphate
0 ImagesCat. No.: HY-113002CAS No.: 10139-18-1α-D-Glucose 1,6-bisphosphate is an activator of PMM2 and phosphoglucomutase. α-D-Glucose 1,6-bisphosphate regulates glycogen metabolism, glycolysis, amino sugar synthesis, as well as the formation of bacterial cell walls and capsules. α-D-Glucose 1,6-bisphosphate can be used in studies related to pmm2-cdg (cdg-1a or Jaeken syndrome).
